TY - JOUR
AU - 
AB - Human cancer cells overexpress many peptide receptors as molecular targets. Radiolabeled peptides that bind with high affinity and specificity to the receptors on tumor cells hold great potential for both diagnostic imaging and targeted radionuclide therapy. The advantage of solid-phase peptide synthesis, the availability of different chelating agents and prosthetic groups and bioconjugation techniques permit the facile preparation of a wide variety of peptide-based targeting molecules with diverse biological and tumor targeting properties. Some of these peptides, including somatostatin, bombesin, vasoactive intestinal peptide, gastrin, neurotensin, exendin and RGD are currently under investigation. It is anticipated that in the near future many of these peptides may find applications in nuclear oncology. This ar- ticle presents recent developments in the field of small peptides, and their applications in the diagnosis and treatment of cancer. Key words: Radiolabeled peptides, tumor imaging, radionuclide therapy, radionuclides Introduction Molecular imaging techniques are increasingly therapy [1-4]. Peptides primarily synthesized in the being used in the localization of disease, the staging of brain, especially in neurons, are called “neuropep- disease and for therapy control. The most sensitive tides” [2, 3]. However, since most of these peptides imaging methods are those using nuclear probes for are also found 
TI - Radiolabeled Peptides: Valuable Tools for the Detection and Treatment of Cancer
JF - Theranostics
DO - 10.7150/thno.4024
DA - 2012-01-01
UR - https://www.deepdyve.com/lp/unpaywall/radiolabeled-peptides-valuable-tools-for-the-detection-and-treatment-yRPrWaMZzm
DP - DeepDyve
ER -