TY - JOUR
AU1 - Miller, Michael
AU2 - Bhatt, Deepak L
AU3 - Brinton, Eliot A
AU4 - Jacobson, Terry A
AU5 - Steg, Philippe Gabriel
AU6 - Pineda, Armando Lira
AU7 - Ketchum, Steven B
AU8 - Doyle, Ralph T
AU9 - Tardif, Jean-Claude
AU1 - Ballantyne, Christie M
AB - AimsMetabolic syndrome (MetSyn) is associated with high risk of cardiovascular (CV) events, irrespective of statin therapy. In the overall REDUCE-IT study of statin-treated patients, icosapent ethyl (IPE) reduced the risk of the primary composite endpoint (CV death, non-fatal myocardial infarction, non-fatal stroke, coronary revascularization, or unstable angina requiring hospitalization) and the key secondary composite endpoint (CV death, non-fatal myocardial infarction, or non-fatal stroke).Methods and resultsREDUCE-IT was an international, double-blind trial that randomized 8179 high CV risk statin-treated patients with controlled LDL cholesterol and elevated triglycerides to IPE 4 g/day or placebo. The current study evaluated the pre-specified patient subgroup with a history of MetSyn, but without diabetes at baseline. Among patients with MetSyn but without diabetes at baseline (n = 2866), the majority (99.8%) of this subgroup was secondary prevention patients. Icosapent ethyl use was associated with a 29% relative risk reduction for the first occurrence of the primary composite endpoint [hazard ratio: 0.71; 95% confidence interval (CI): 0.59–0.84; P < 0.0001, absolute risk reduction (ARR) = 5.9%; number needed to treat = 17] and a 41% reduction in total (first plus subsequent) events [rate ratio: 0.59; (95% CI: 0.48–0.72); P < 0.0001] compared with placebo. The risk for the key secondary composite endpoint was reduced by 20% (P = 0.05) and a 27% reduction in fatal/non-fatal MI (P = 0.03), 47% reduction in urgent/emergent revascularization (P < 0.0001), and 58% reduction in hospitalization for unstable angina (P < 0.0001). Non-statistically significant reductions were observed in cardiac arrest (44%) and sudden cardiac death (34%).ConclusionIn statin-treated patients with a history of MetSyn, IPE significantly reduced the risk of first and total CV events in REDUCE-IT. The large relative and ARRs observed supports IPE as a potential therapeutic consideration for patients with MetSyn at high CV risk.Registration REDUCE-IT ClinicalTrials.gov number: NCT01492361
TI - Effectiveness of icosapent ethyl on first and total cardiovascular events in patients with metabolic syndrome, but without diabetes: REDUCE-IT MetSyn
JF - European Heart Journal Open
DO - 10.1093/ehjopen/oead114
DA - 2023-11-12
UR - https://www.deepdyve.com/lp/oxford-university-press/effectiveness-of-icosapent-ethyl-on-first-and-total-cardiovascular-xm5BGGdbV6
VL - 3
IS - 6
DP - DeepDyve
ER -