TY - JOUR
AU - Khamidov, D.
AB - EFFECT OF THYROXINE ON~TRANSMEMBRANE POTENTIAL OF RAT LIVER MITOCHONDRIA IN VITRO T. Yu. Koval', A. I. Gagel' gans, UDC 612.352.015.3:577.121.7].014.46: and D. Kh. Khamidov* 615.357.441:577.175.444 KEY WORDS: transmembrane potential; thyroxine; rat liver mitochondria Research into the mechanism of action of thyroid hormones on energy metabolism in the mitochondria and, in particular, their influence on transmembrane potential, has recently been published [3, 4], As long ago as in 1971-72, the present writers [2] made successful attempts to determine the transmembrane potential by Mitchell's method [9, I0]. Since the mechanism of action of thyroid hormones on the energetic parameters of the mitochondria still remains an urgent problem, we decided to continue these experiments. It has been suggested [9] that the mitochondria membrane is impermeable for H + and OH- ions. Accmmulation of H + and OH- in two aqueous phases separated by a membrane is used to form ATP from ADP + Pi, through the action of ATPase. The membrane potential (&~) is not determined entirely by the H + gradient (ApH), for an exchange-diffusion system, exchanging H + for cations and OH- for anions operates in mitochondria. The membrane potential level required for ATP synthesis is approximately 200 mV at 
TI - Effect of thyroxine on transmembrane potential of rat liver mitochondria in vitro
JO - Bulletin of Experimental Biology and Medicine
DO - 10.1007/BF00845077
DA - 2004-12-03
UR - https://www.deepdyve.com/lp/springer-journals/effect-of-thyroxine-on-transmembrane-potential-of-rat-liver-xRvH3W8iWb
SP - 1550
EP - 1553
VL - 104
IS - 5
DP - DeepDyve
ER -