TY - JOUR
AU - Nightingale, Brian N.
AB - To determine the influence of concurrent human immunodeficiency virus (HIV) infection on chronic hepatitis B virus (HBV) infection, 150 male homosexual chronic hepatitis B surface antigen (HBsAg) carriers were studied. Of these, 82 subjects (55%) tested positive for antibodies to HIV. They were more likely to express hepatitis B “e” antigen (HBeAg) (P < .001) and HBV-DNA (P < .0005) in serum than were HIV-seronegative individuals. However, the degree of immune suppression did not influence HBeAg-HBV-DNA expression. In HBeAg-seropositive subjects, concurrent HIV infection was associated with lower serum alanine transferase levels (P < .001). This effect increased with the degree of immune suppression as determined by CD4+ lymphocyte counts. Conversely, in patients negative for HBeAg, there was a weak trend towards higher alanine transferase levels with concurrent HIV. This study suggests that chronic hepatitis B may be less severe when accompaned by HIV infection; however, greater viral replication may make it more contagious and resistant to antiviral therapy. These data support an immune-mediated pathogenesis for hepatitis B and have implications for its control.
TI - The Effect of Concurrent Human Immunodeficiency Virus Infection on Chronic Hepatitis B: A Study of 150 Homosexual Men
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/160.4.577
DA - 1989-10-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-effect-of-concurrent-human-immunodeficiency-virus-infection-on-xQUzUJv95d
SP - 577
EP - 582
VL - 160
IS - 4
DP - DeepDyve
ER -