TY - JOUR
AU1 - Jones, John, I.
AU2 - Clemmons, David, R.
AB - Downloaded from https://academic.oup.com/edrv/article-abstract/16/1/3/2548486 by guest on 15 October 2019 0163-769X/95/$03.00/0 Vol. 16, No. 1 Printed in U.S.A. Endocrine Reviews Copyright © 1995 by The Endocrine Society Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions* JOHN I. JONES AND DAVID R. CLEMMONS Division of Endocrinology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7170 I. Introduction I. Introduction HE insulin-like growth factors were discovered on the II. Signal Transduction via IGF Receptors T basis of their ability to stimulate cartilage sulf ation and A. IGF-I receptor to replace the "sulfation factor activity" of GH, as determined 1. Extracellular domain/ligand binding using an in vivo assay, in an in vitro test system (1). The 2. Cytoplasmic domain biological significance of this finding was quickly expanded 3. Signal transduction beyond the study of cartilage sulf ation to include stimulation 4. Hybrid insulin/IGF-I receptors of DNA synthesis (2), proteoglycan synthesis (3), glycosami- B. IGF-II/mannose-6-phosphate receptor noglycan synthesis (4), and protein synthesis (5). Most of 1. Ligand binding these studies used tissue preparations such as isolated dia- 2. Deletion of IGF-II receptor/parental imprinting phragm, cartilage, or epididymal fat pads to study biological 3. Possible signaling functions activity. In recognition of 
TI - Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions
JF - Endocrine Reviews
DO - 10.1210/edrv-16-1-3
DA - 1995-02-01
UR - https://www.deepdyve.com/lp/oxford-university-press/insulin-like-growth-factors-and-their-binding-proteins-biological-xMGRiVoJBV
SP - 3
VL - 16
IS - 1
DP - DeepDyve
ER -