TY - JOUR
AU - Li, Dan
AB - Technology, Faculty of Science, Aims: To compare the heat stability of two globally prevalent human norovirus National University of Singapore, (HuNoV) strains (GII.2[P16] and GII.4[P16]) and a commonly used HuNoV surro- Singapore, Singapore Institute of Microbiology, Guangdong gate, Tulane virus (TV). Academy of Sciences, Guangzhou, Methods and Results: With the use of a newly developed zebrafish larvae plat- China form, we measured the change of infectivity of HuNoV GII.2[P16] and GII.4[P16] Department of Food Science and toward mild heat treatment at 55°C for 5 min. TV was tested with the same experi- Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, mental design. As a result, the virus infectivity measurement clearly indicated the Shanghai, China higher heat resistance of HuNoV GII.2[P16] (no reduction) than GII.4[P16] (>0.8- log Department of Biological Sciences, −1 −1 TCID  ml reduction) and TV (2.5- log TCID  ml reduction). Further exploration 50 50 Faculty of Science, National University of Singapore, Singapore, Singapore revealed higher virus structural stability of HuNoV GII.2 than GII.4 strains by the use of different clinical samples with different evaluation methods. Correspondence Conclusion: The inactivation data generated from the surrogate virus TV cannot be Dan Li, Department F of ood Science & 
TI - The globally re‐emerging norovirus GII.2 manifests higher heat resistance than norovirus GII.4 and Tulane virus
JO - Journal of Applied Microbiology
DO - 10.1111/jam.15379
DA - 2022-03-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-globally-re-emerging-norovirus-gii-2-manifests-higher-heat-xHTwVMhuC0
SP - 2441
EP - 2449
VL - 132
IS - 3
DP - DeepDyve
ER -