TY - JOUR
AU1 - Lipka, J.J.
AU2 - Miyoshi, I.
AU3 - Hadlock, K.G.
AU4 - Reyes, G.R.
AU5 - Chow, T.P.
AU6 - Blattner, W.A.
AU7 - Shaw, G.M.
AU8 - Hanson, C.V.
AU9 - Gallo, D.
AU1 - Chan, L.
AU1 - Foung, S.K.H.
AB - A recombinant protein of the human T cell lymphotropic virus type I (HTLV-I) gp46 outer membrane envelope, MTA-4 (residues 129–203), reacted by Western blot with sera from HTLVI- infected individuals from the United States and Jamaica but not with 24 (10%) of 242 Japanese sera. A related gp46 recombinant protein, MTA-1 (residues 162–209), reacted with all 58 sera from HTLV-I-infected US and Jamaican individuals and 238 of 242 sera from infected Japanese (combined sensitivity of 99%). Neither recombinant showed reactivity to sera from HTLV-II-infected individuals or uninfected controls. The reactivity of recombinant proteins containing the region of HTLV-II gp46 analogous to MTA-1 was also evaluated by Western blot: GH2-KI5 (residues 157–205) and GH2-K55 (residues 162–205) reacted with 88 (98%) and 89 (99%), respectively, of 90 sera from HTLV-II-infected individuals but not with sera from HTLV-I-infected individuals or uninfected controls. These recombinant proteins should permit the development of assays to unambiguously confirm and differentiate HTLV-I and HTLV-II infections.
TI - Segregation of Human T Cell Lymphotropic Virus Type I and II Infections by Antibody Reactivity to Unique Viral Epitopes
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/165.2.268
DA - 1992-02-01
UR - https://www.deepdyve.com/lp/oxford-university-press/segregation-of-human-t-cell-lymphotropic-virus-type-i-and-ii-xCIPVPotrs
SP - 268
EP - 272
VL - 165
IS - 2
DP - DeepDyve
ER -