TY - JOUR
AU1 - BURSTEIN, SHLOMO
AU2 - SAVARD, KENNETH
AU3 - DORFMAN, RALPH I.
AB - Abstract The isolation of the C-19 and C-21 saturated urinary metabolites following cortisone administration to man have been described (Dobriner et al., 1950, 1951; Burstein et al., 1953). Recently significant quantities of hydrocortisone (17-hydroxycorticosterone) have become available and the present study reports the isolation from urine, utilizing paper chromatography, of the major α-ketolic and 17-ketosteroid metabolites isolated following the oral administration of hydrocortisone to a man. The isolated steroids were identified by chromatographic mobility on paper, melting points and infra-red spectrometry. The significance of the present study lies in the demonstration of: 1) The in vivo conversion of hydrocortisone into cortisone, 2) the products of reduction of the Δ4-3-keto system, and 3) the pattern of the 11-oxygenated 17-ketosteroid metabolites arising from hydrocortisone. This content is only available as a PDF. Author notes 1 Supported in part by Contracts No. DA-49-007-MD-1S4 and No. DA-49-007-MD-135 (administered by Dr. G. W. Thorn, Harvard University) Medical Research and Development Board, Office of the Surgeon General, Department of the Army, and in part of U. S. Public Health Service Grants G-3247 (C1) and A-19 (C2) (administered by Dr. G. W. Thorn). Copyright © 1953 by The Endocrine Society
TI - THE IN VIVO METABOLISM OF HYDROCORTISONE
JF - Endocrinology
DO - 10.1210/endo-53-1-88
DA - 1953-07-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-in-vivo-metabolism-of-hydrocortisone-x0VmgdbdTV
SP - 88
EP - 97
VL - 53
IS - 1
DP - DeepDyve
ER -