TY - JOUR
AU - Dai, Yuanwei
AB - Glycosylation is an important strategy to improve the druggability of lead compounds. Here, we present a palladium-catalysed stereospecific N-glycosylation of sulfonamides. This approach stands out with wide substrate scope, high functional group tolerance, and easy scalability, furnishing a broad spectrum of densely functionalized β-N-glycosyl sulfonamides with good efficiency and exceptional regio-/stereoselectivity. Diverse drug-like glycosulfonamido scaffolds have been constructed via a late-stage diversification strategy and various facile synthetic transformations of the products. Collectively, the established protocol provides a valuable tool for efficiently preparing glycosyl sulfonamides to facilitate drug discovery.
TI - Facile and stereospecific synthesis of diverse β-N-glycosyl sulfonamide scaffolds via palladium catalysis
JF - Chemical Communications
DO - 10.1039/d3cc04063a
DA - 2023-10-26
UR - https://www.deepdyve.com/lp/royal-society-of-chemistry/facile-and-stereospecific-synthesis-of-diverse-n-glycosyl-sulfonamide-x0ShzddR8R
SP - 12907
EP - 12910
VL - 59
IS - 86
DP - DeepDyve
ER -