TY - JOUR AU - Amé, María Valeria AB - INTRODUCTIONChlorpyrifos and cypermethrin concentrations were reported together in aquatic environments worldwide during the last 15 yr . In Argentinean basins, the concentrations of these pesticides can range from less than 0.2 ng/L to 3.5 µg/L for cypermethrin and 0.2 ng/L to 17 µg/L for chlorpyrifos . Cypermethrin and chlorpyrifos belong to pyrethroids and organophosphorus pesticides, respectively, and such a combination is common in pesticide applications both in households and in agricultural activities .Mixed pesticides, compared with single pesticides, could cause significant synergistic effects of toxicity on target species, although they are also effective on nonpest species such as invertebrate or fish. Denton et al. reported synergistic effects when mixtures of diazinon (organophosphorus insecticide) and esfenvalerate (pyrethroid insecticide) were tested using fish larvae fathead minnows (Pimephales promelas). Atrazine (herbicide of the triazine class) exposures in mixtures with chlorpyrifos significantly increase the inhibition of cholinesterase enzyme activity and chlorpyrifos‐uptake kinetics in Xenopus laevis and P. promelas . However, mixtures of carbofuran (carbamate insecticide) and methamidophos (organophosphorus insecticide) exhibit a synergic or partial additive in the median lethal concentration values (LC50) after 96 h of exposure on trout larvae Oncorhynchus mykiss . In addition, Brodeur et al. observed synergistic effects in the value of LC50 in tadpoles (Rhinella TI - Tissue‐specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (Jenynsia multidentata) exposed to these insecticides singly and in mixtures JO - Environmental Toxicology and Chemistry DO - 10.1002/etc.3613 DA - 2017-07-01 UR - https://www.deepdyve.com/lp/oxford-university-press/tissue-specific-bioconcentration-and-biotransformation-of-cypermethrin-wtWOn4a0NP SP - 1764 EP - 1774 VL - 36 IS - 7 DP - DeepDyve ER -