TY - JOUR
AU - Jemielity, Jacek
AB - Abstract The syntheses of mRNA cap analogs modified with boranophosphate moiety at either the α or β-position of the 5′, 5′-triphosphate bridge (m7GpppBH3G, m7GppBH3pG and m7GppBH3pm7G) are described. The preliminary biological characterization of these compounds revealed that they have high affinity for translational factor eIF4E and high potency to inhibit cap-dependent translation in cell free system. The analogs modified at the β-position were also found to be resistant to DcpS decapping pyrophosphatase. © 2008 Oxford University Press
TI - The first examples of mRNA cap analogs bearing boranophosphate modification
JO - Nucleic Acids Symposium Series
DO - 10.1093/nass/nrn146
DA - 2008-09-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-first-examples-of-mrna-cap-analogs-bearing-boranophosphate-wqIsWfHJqQ
SP - 289
EP - 290
VL - 52
IS - 1
DP - DeepDyve
ER -