TY - JOUR
AU1 - Liu, Li
AU2 - Patra, Abhijit
AU3 - Scherf, Ullrich
AU4 - Kissel, Thomas
AB - An ultra‐bright fluorescence probe comprising conjugated polymer nanoparticles is developed for biological imaging. Highly blue fluorescent polyfluorene nanoparticles (PF‐NPs) stabilized by sodium dodecylsulfate with an average diameter of 100 nm are prepared by a miniemulsion technique. A folate‐conjugated cationic triblock copolymer is employed to coat negatively charged PF‐NPs via electrostatic interaction for specific cell imaging of folate receptor over‐expressing cancer cells. The coated PF‐NPs show a similar size and morphology to the pristine PF‐NPs, while the fluorescence intensity is enhanced. Such surface‐functionalized PF‐NPs are demonstrated to be suitable probes for efficient cell imaging of folate receptor over‐expressing KB cells by CLSM and flow cytometry.
TI - Polyfluorene Nanoparticles Coated with Folate‐Functionalized Triblock Copolymer: Effective Agents for Targeted Cell Imaging
JF - Macromolecular Bioscience
DO - 10.1002/mabi.201200144
DA - 2012-10-01
UR - https://www.deepdyve.com/lp/wiley/polyfluorene-nanoparticles-coated-with-folate-functionalized-triblock-woJoQOI0pg
SP - 1384
EP - 1390
VL - 12
IS - 10
DP - DeepDyve
ER -