TY - JOUR
AU - Solomon, Donald D.
AB - Vascular catheters coated with antiinfective compounds were evaluated as to their ability to prevent Staphylococcus aureus catheter infection in a rabbit model. Zones of inhibition of agar surface-plated S. aureus demonstrated the following hierarchy: dicloxacillin and clindamycin were each better than fusidic acid or chlorhexidine, which were better than ciprofloxacin, cefotaxime, or cefuroxime. In vivo half-lives of inhibitory activity for clindamycin and dicloxacillin were 5.6 and 17.7 h, respectively, with apparent first-order kinetics. Chlorhexidine disappeared in vivo with apparent two-compartment kinetics: first-compartment t1/2, 16.8 h; second-compartment tl/2, 115.6 h. In a rabbit model, dicloxacillin, clindarnycin, fusidic acid, and chlorhexidine decreased the risk of infection compared with uncoated control catheters (P < .05). For dicloxacillin, clindamycin, and chlorhexidine, this was true even if the S. aureus inoculation was delayed 48 or 96 h after catheter implantation. These data suggest that vascular catheters with antiinfective coatings should be investigated further in hospitalized patients.
TI - Efficacy of Antibiotic-Coated Catheters in Preventing Subcutaneous Staphylococcus aureus Infection in Rabbits
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/167.1.98
DA - 1993-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/efficacy-of-antibiotic-coated-catheters-in-preventing-subcutaneous-wnSICkFsU8
SP - 98
EP - 106
VL - 167
IS - 1
DP - DeepDyve
ER -