TY - JOUR
AU - Gu, Haiyong
AB - Esophageal cancer is the sixth most common cancer worldwide. Esophageal squamous cell carcinoma (ESCC) is a fatal malignancy associated with low 5-year survival rate. The aim of this study was to assess the association between methylenetetrahydrofolate reductase (MTHFR) tagging single nucleotide polymorphisms (SNPs) rs1801133 C>T, rs3753584 A>G, rs4845882 G>A, rs4846048 A>G and rs9651118 T>C genotypes and ESCC susceptibility in a hospital-based case–control study. We conducted genotyping analyses for these five SNPs with 629 ESCC cases and 686 controls in a Chinese Han population. Ligation detection reaction method was used to identify genotypes of these MTHFR SNPs. Our results demonstrated that MTHFR rs1801133 C>T was associated with the risk of ESCC; however, MTHFR rs4845882 G>A and rs4846048 A>G SNPs were associated with the decreased risk of ESCC, and MTHFR rs3753584 A>G and rs9651118 T>C SNPs were not associated with ESCC risk. Our findings suggests that MTHFR rs1801133 C>T, rs4845882 G>A and rs4846048 A>G SNPs may be genetic modifiers for developing ESCC in Chinese Han population.
TI - Genetic variations in MTHFR and esophageal squamous cell carcinoma susceptibility in Chinese Han population
JF - Medical Oncology
DO - 10.1007/s12032-014-0915-6
DA - 2014-04-01
UR - https://www.deepdyve.com/lp/springer-journals/genetic-variations-in-mthfr-and-esophageal-squamous-cell-carcinoma-wN6v39VtEG
SP - 1
EP - 7
VL - 31
IS - 5
DP - DeepDyve
ER -