TY - JOUR
AU1 - Burton, John L.
AB - Abstract To the Editor.— In the November 1986 issue of the Archives, Watanabe et al1 described two patients with multiple cutaneous plasma cell infiltrates, polyclonal hypergammaglobulinemia, and generalized lymphadenopathy that showed the histologic features of Castleman's giant lymph node hyperplasia. I should like to highlight some similarities between this interesting syndrome and the Crow-Fukase syndrome (also called Shimpo's syndrome, Tatsuki syndrome, PEP syndrome, and POEMS syndrome).2 In the latter syndrome, hyperglobulinemia, which may be polyclonal or monoclonal, is associated with polyneuropathy and a variety of cutaneous and endocrinologic manifestations including edema, pigmentation, scleroderma, gynecomastia, and impotence. Only approximately 50% of cases have evidence of multiple myelomatosis. Generalized lymphadenopathy occurs in the majority of cases, and the lymph nodes often show Castleman's angiofollicular hyperplasia with sheets of mature plasma cells as described by Watanabe and colleagues in their two cases of systemic plasmacytosis. In the Crow-Fukase syndrome, the changes are References 1. Watanabe S, Ohara K, Kukita A, et al: Systemic plasmacytosis: A syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia . Arch Dermatol 1986;122:1314-1320.Crossref 2. Burton JL: Peripheral neuropathy associated with dysproteinaemia, skin changes and endocrinopathy . Br Med J 1986; 292:1415-1416.Crossref 3. Nakanishi T, Sobue I, Toyokura Y, et al: The Crow-Fukase syndrome: A study of 102 cases in Japan . Neurology 1984;34:712-720.Crossref 4. Saihan EM, Burton JL, Heaton KW: A new syndrome with pigmentation, scleroderma, gynaecomastia, Raynaud's phenomenon and peripheral neuropathy . Br J Dermatol 1978;99:437-440.Crossref 5. Shelley WB, Shelley ED: The skin changes in the Crow-Fukase (POEMS) syndrome: A case report . Arch Dermatol 1987;123:85-87.Crossref
TI - Systemic Plasmacytosis and the Crow-Fukase Syndrome
JF - Archives of Dermatology
DO - 10.1001/archderm.1987.01660280025007
DA - 1987-04-01
UR - https://www.deepdyve.com/lp/american-medical-association/systemic-plasmacytosis-and-the-crow-fukase-syndrome-wM2KuxRpsN
SP - 425
EP - 426
VL - 123
IS - 4
DP - DeepDyve
ER -