TY - JOUR
AU - KAPLAN, N., L.
AB - Abstract Advances in understanding carcinogenesis have led to the development of mathematical models that have biologically interpretable parameters. These models utilize more of the available scientific data than the empirical models routinely employed for quantifying carcinogenic risk. They also require consideration of sources of uncertainty in risk estimates that were previously ignored, such as animal-to-animal variability of physiological and pharmacological constants. A numerical technique is proposed for studying the consequences of incorporating the intrapopulation variability of biologically interpretable parameters into the risk assessment process. To demonstrate the technique, the variability of safe dose estimates for exposure to methylene chloride is considered. The results suggest that intrapopulation variability of the model parameters can increase the variability of safe dose estimates an appreciable amount. This content is only available as a PDF. © 1989 by the Society of Toxicology
TI - Variability of Safe Dose Estimates When Using Complicated Models of the Carcinogenic ProcessA Case Study: Methylene Chloride
JF - Toxicological Sciences
DO - 10.1093/toxsci/13.3.533
DA - 1989-10-01
UR - https://www.deepdyve.com/lp/oxford-university-press/variability-of-safe-dose-estimates-when-using-complicated-models-of-vtkhyOzcrP
SP - 533
EP - 544
VL - 13
IS - 3
DP - DeepDyve
ER -