TY - JOUR
AU1 - Pastore, Yves
AU2 - Lajaunias, Frédéric
AU3 - Kuroki, Aki
AU4 - Moll, Thomas
AU5 - Kikuchi, Shuichi
AU6 - Izui, Shozo
AB - Springer Semin Immunopathol (2001) 23:315-329 Springer Seminars in Immunopathology 9 Springer-Verlag 2001 An experimental model of cryoglobulin-associated vasculitis in mice Yves Pastore, Fr6d~ric Lajaunias, Aki Kuroki, Thomas Moll, Shuichi Kikuchi, Shozo Izui Departmenl of Pathology, University of Geneva. 1211 Geneva 4, Switzerland Introduction Cryoglobulins are immunoglobulins (Ig) that precipitate at temperatures lower than 37~ with resolution upon warming [1-3]. Since their initial characterization by Lerner et al. [1 ], it has been recognized that they are not a single distinct group of Ig, but heterogeneous with respect to their composition and physical properties. Cryo- globulins can be classified into three types [3] according to the presence in the cryo- precipitates of: monoclonal lg (type I), both monoclonal and polyclonal Ig (type II), or polyclonal ig with or without other serum proteins or exogenous antigens (type III). Monoclonal type I cryoglobulins are mostly associated with various lymphopro- liferative disorders. Mixed type 1I or type III cryoglobulins are often found in serum from patients with atitoimmune diseases such as systemic hipus erythematosus and rheumatoid arthritis or with a variety of chronic infectious diseases. Clearly, the interaction between Ig molecules plays a critical role in the formation of cryoglobulins, since the sole 
TI - An experimental model of cryoglobulin-associated vasculitis in mice
JF - Seminars in Immunopathology
DO - 10.1007/s002810100075
DA - 2001-09-01
UR - https://www.deepdyve.com/lp/springer-journals/an-experimental-model-of-cryoglobulin-associated-vasculitis-in-mice-vtjG0jY2Hj
SP - 315
EP - 329
VL - 23
IS - 3
DP - DeepDyve
ER -