TY - JOUR
AU - Rune, S.J.
AB - Editorial Digestion 8: 261-268 (1973) Its Physiological and Pathophysiological Significance S. J. R une Medical Department B, Genlofte Hospital, Copenhagen Key Words Bicarbonates Pancreatic juice Duodenal ulcer Pancreatitis Duodenum pH Gastric acidity determination Secretin Neutralization of the acid gastric contents when these are emptied into the duodenum is essential for several reasons: (1) Pancreatic enzymes are inactivated at a low pH, the most vulnerable is lipase, which is irreversibly denaturated at pH 3 [14], (2) The solubility o f bile acids and their micelles decrease at a low pH [6], (3) Non-ionic diffusion of bile acids through upper small intestinal mucosa increases with decreasing luminal pH [8], (4) Acid causes damage to the intestinal epithelium in varying degrees from micro­ scopic oedema, infiltration with inflammatory cells and reduction o f villus height [31] to macroscopic ulceration and necrosis, as shown experimentally by shunting out bile and pancreatic juice from the duodenum [11, 15, 21] or by administration of exogenous gastrin [10, 19]. Duodenal pH in Normal Subjects As a consequence of the neutralizing processes, considerable pH gra­ dients are found within the duodenum. Apart from a short period after a meal, the pH o f the gastric contents is 
TI - pH in the Human Duodenum
JF - Digestion
DO - 10.1159/000197323
DA - 1973-01-01
UR - https://www.deepdyve.com/lp/karger/ph-in-the-human-duodenum-vMb7S5ssWw
SP - 261
EP - 268
VL - 8
IS - 3
DP - DeepDyve
ER -