TY - JOUR
AU1 - Jang,, Kyung-Lib
AU2 - Pulverer,, Bemd
AU3 - Woodgett, James, R.
AU4 - Latchman, David, S.
AB - Abstract Lytic infection with herpes simplex virus (HSV) results in the repression of most host cell protein synthesis but produces an increased activity of the cellular AP-1 transcription factor. This increase Is paralleled by an increase In the transcription rate of the proto-oncogene encoding the AP-1 component, c-Jun resulting in an increase in c-Jun protein In infected cells. The increased AP-1 activity in infected cells is dependent upon the HSV immediate-early protein ICPO. Thus a mutant lacking the gene encoding this protein falls to increase AP-1 activity whilst an ICPO expression plasmid can specifically increase the activity of an AP-1 dependent promoter in co-transfection experiments. The Implications of these effects in the interaction of HSV with cultured cells are discussed. This content is only available as a PDF. © 1991 Oxford University Press
TI - Activation of the cellular transcription factor AP-1 in herpes simplex virus infected cells is dependent on the viral immediate-early protein ICPO
JF - Nucleic Acids Research
DO - 10.1093/nar/19.18.4879
DA - 1991-09-25
UR - https://www.deepdyve.com/lp/oxford-university-press/activation-of-the-cellular-transcription-factor-ap-1-in-herpes-simplex-vHg7D07M2y
SP - 4879
EP - 4883
VL - 19
IS - 18
DP - DeepDyve
ER -