TY - JOUR
AU1 - Choi, Yong Hwan
AU2 - Son, Kun Ho
AU3 - Chang, Hyeun Wook
AU4 - Bae, KiHwan
AU5 - Kang, Sam Sik
AU6 - Kim, Hyun Pyo
AB - Synurus deltoides was previously found to possess significant anti-inflammatory activity especially against chronic inflammation, and strong analgesic activityin vivo. In this study, new anti-inflammatory formulation containingS. deltoides extract as a major ingredient was prepared andin vivo activity was evaluated. The plausible action mechanism was also investigated. The new formulation (SAG) contains 1 part ofS. deltoides extract, 0.9 part ofAngelica gigas extract and 0.9 part of glucosamine sulfate (w/w). SAG inhibited dose-dependently edematic response of arachidonic acid (AA)- and 12-O-tetradecanoyl 13-acetate (TPA)-induced ear edema in mice, which is an animal model of acute inflammation. SAG showed 44.1% inhibition of AA-induced ear edema at an oral dose of, 50 mg/kg. In an animal model of chronic inflammation, SAG clearly reduced the edematic response of 7-day model of multiple treatment of TPA (38.1% inhibition at 200 mg/kg/day). Furthermore, SAG (50–800 mg/kg/day) as well asS. deltoides extract (285 mg/kg/day) significantly inhibited prostaglandin E2 production from the skin lesion of the animals of 7-day model. These results were well correlated within vitro finding that SAG as well asS. deltoides extract reduced cyclooxygenase (COX)-1- and COX-2-induced prostanoid production, measured in mouse bone marrow-derived mast cells. There-fore, these results suggest that SAG possesses anti-inflammatory activityin vivo against acute as well as chronic inflammatory animal models at least in part by inhibition of prostaglandin production through COX-1/COX-2 inhibition. And COX inhibition of SAG is possibly contributed byS. deltoides extract among the ingredients. Although the anti-inflammatory potencies of SAG were less than those of currently used anti-inflammatory drugs, this formulation may have beneficial effect on inflammatory disorders as a neutraceutical.
TI - New anti-inflammatory formulation containingSynurus deltoides extract
JF - Archives of Pharmacal Research
DO - 10.1007/bf02977352
DA - 2005-07-01
UR - https://www.deepdyve.com/lp/springer-journals/new-anti-inflammatory-formulation-containingsynurus-deltoides-extract-uxe1P0lPGe
SP - 848
EP - 853
VL - 28
IS - 7
DP - DeepDyve
ER -