TY - JOUR
AU - Saha, Badal
AB - Recently, itaconic acid (IA), an unsaturated C5-dicarboxylic acid, has attracted much attention as a biobased building block chemical. It is produced industrially (>80 g L−1) from glucose by fermentation with Aspergillus terreus. The titer is low compared with citric acid production (>200 g L−1). This review summarizes the latest progress on enhancing the yield and productivity of IA production. IA biosynthesis involves the decarboxylation of the TCA cycle intermediate cis-aconitate through the action of cis-aconitate decarboxylase (CAD) enzyme encoded by the CadA gene in A. terreus. A number of recombinant microorganisms have been developed in an effort to overproduce it. IA is used as a monomer for production of superabsorbent polymer, resins, plastics, paints, and synthetic fibers. Its applications as a platform chemical are highlighted. It has a strong potential to replace petroleum-based methylacrylic acid in industry which will create a huge market for IA.
TI - Emerging biotechnologies for production of itaconic acid and its applications as a platform chemical
JF - Journal of Industrial Microbiology  Biotechnology
DO - 10.1007/s10295-016-1878-8
DA - 2016-12-08
UR - https://www.deepdyve.com/lp/springer-journals/emerging-biotechnologies-for-production-of-itaconic-acid-and-its-uSEffDZHXy
SP - 303
EP - 315
VL - 44
IS - 2
DP - DeepDyve
ER -