TY - JOUR
AU - Bigner,  Darell D.
AB - Purpose : To further evaluate the activity of irinotecan (CPT-11) plus 1,3-bis-(chloroethyl)-1-nitrosourea (BCNU) in the treatment of central nervous system tumor-derived xenografts in athymic nude mice. Methods : We report studies evaluating the schedule- dependence of this regimen in the treatment of the malignant glioma xenograft D-54 MG. Results : The combination of BCNU and CPT-11 showed the highest enhancement index (2.0–3.3) when BCNU was given on day 1 and CPT-11 was given on days 1–5 and 8–12. Delay of CPT-11 administration to day 3 or day 5 substantially decreased activity with enhancement indices of 1.6–1.8 and 0.6–1.0, respectively. Delay of BCNU administration to day 8 also reduced the CPT-11 activity with enhancement indices of 1.2–1.4. Conclusions : These results suggest that the presence of a BCNU- induced adduct or possibly crosslink prior to administration of CPT-11 is critical for enhanced activity. Although the mechanism of this enhancement is not currently known, a phase I trial of CPT-11 plus BCNU for adults with recurrent malignant glioma based on these results is in progress.
TI - Schedule-dependent activity of irinotecan plus BCNU against malignant glioma xenografts
JF - Cancer Chemotherapy and Pharmacology
DO - 10.1007/s002800050050
DA - 2000-03-01
UR - https://www.deepdyve.com/lp/springer-journals/schedule-dependent-activity-of-irinotecan-plus-bcnu-against-malignant-uRgBpbk0At
SP - 345
EP - 349
VL - 45
IS - 4
DP - DeepDyve
ER -