TY - JOUR
AU1 - Farnetani, Ginevra
AU2 - Fino, Maria Grazia
AU3 - Cioppi, Francesca
AU4 - Riera‐Escamilla, Antoni
AU5 - Tamburrino, Lara
AU6 - Vannucci, Matteo
AU7 - Rosta, Viktoria
AU8 - Vinci, Serena
AU9 - Casamonti, Elena
AU1 - Turki, Leila
AU1 - Degl'Innocenti, Selene
AU1 - Spinelli, Matilde
AU1 - Marchiani, Sara
AU1 - Lotti, Francesco
AU1 - Muratori, Monica
AU1 - Krausz, Csilla
AB - INTRODUCTIONTesticular germ cell tumor (TGCT) is the most frequent malignancy in men of reproductive age.1 Its incidence has risen by 1.5% worldwide in the past two decades, presenting sharp geographic differences with the highest incidence in Caucasian populations.1–3 Thanks to the progress in diagnosis and treatment, TGCT is now highly curable with an overall 5‐year survival rate of 95%.4 The primary treatment is radical inguinal orchiectomy, which can be followed by chemotherapy (CT) and/or radiotherapy (RT), depending on the histology and staging.5 CT usually includes platinum‐based agents, such as carboplatin (CP) or a combination of bleomycin, etoposide, and cisplatin (BEP), while RT is recommended only in seminoma (stage IIA and IIB).5Antineoplastic treatments exert their effect by inducing DNA fragmentation in proliferating cells. Hence, they often lead to spermatogenic impairment (severe oligozoospermia or azoospermia) as a short‐term effect. In the large majority of cases, a full or partial recovery of the spermatogenesis occurs within 2 years from the end of therapy. Although routine semen parameters return or even ameliorate with respect to the pre‐treatment values, concerns have been raised about the potential long‐term effect of oncological treatments on sperm DNA integrity.6The importance of better characterizing the nature and persistence of 
TI - Long‐term effect of cytotoxic treatments on sperm DNA fragmentation in patients affected by testicular germ cell tumor
JF - Andrology
DO - 10.1111/andr.13429
DA - 2023-11-01
UR - https://www.deepdyve.com/lp/wiley/long-term-effect-of-cytotoxic-treatments-on-sperm-dna-fragmentation-in-uMVDTiUI5Z
SP - 1653
EP - 1661
VL - 11
IS - 8
DP - DeepDyve
ER -