TY - JOUR
AU1 - Moreno, Francisco
AU2 - Kelly, Cindy Crisp
AU3 - Jorgensen, James H.
AU4 - Patterson, Jan Evans
AB - CORRESPONDENCE Sample Size Could Limit the Power of Case-Control examined by banding patterns, the investigators found 15 unique isolates and three clusters of five, two, and two members, respec­ Studies for Determining Risk Factors for Community­ tively, totaling 24 isolates rather than the 22 reported. Similarly, Acquired Methicillin-Resistant Staphylococcus aureus there cannot be a total of four strains among the nine nosocomial MRSA isolates if, as stated, the three clusters contained four, three, SIR- The article by Moreno et al. [1] on the epidemiology of and two isolates, respectively. community-acquired methicillin-resistant Staphylococcus aureus The increase in MRSA acquired in the community is an im­ (MRSA) raises concerns regarding the methodological approach portant trend [4, 5] with far-reaching implications for empirical and conclusions reached by the authors. When no association be­ antibiotic therapy in individuals at high risk for S. aureus infection. tween outcome and exposure variables are found, the possibility Unfortunately, the small number of subjects included in the case­ that the study had insufficient power to detect a true difference control study does not provide sufficient power to determine risk between cases and controls must be explored [2, 3]. Moreno et al. factors for infection, and discrepancies in 
TI - Reply
JF - Clinical Infectious Diseases
DO - 10.1093/clinids/23.4.851-a
DA - 1996-10-01
UR - https://www.deepdyve.com/lp/oxford-university-press/reply-uC0YXRMXCI
SP - 851
EP - 852
VL - 23
IS - 4
DP - DeepDyve
ER -