TY - JOUR
AU - Black-Schaffer, Bernard
AB - THE EFFECT OF NEUTRAL AND ACIDIC POLYSACCHARIDES ON NATURAL RESISTANCE OF MICE TO BACTERIAL CHALLENGE* PETER F. BONVENTREt AND BERNARD BLACK-SCHAFFER From the Department of Microbiology and the Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219 A multitude of complex polysaccha­ of natural resistance to infections (Shilo, rides are known to alter host resistance to 1959; McDermott and Kiser, 1956). bacterial infection. These include bac­ A major difficulty in the interpretation terial endotoxins (lipopolysaccharides), of data on the relationship between bac­ bacterial capsules, yeast cell walls (zym­ terial lipopolysaccharides and altered host osan), and other chemically complex sub­ resistance is the chemical complexity of stances of microbial or botanical origin. endotoxins. Hestrin (1956) has empha­ At times it is possible to demonstrate ei­ sized that a detailed and systematic study ther an increased susceptibility to infec­ of simple polysaccharides and how they tion or an elevated resistance following impinge upon natural resistance might provide a sound basis for explanation of the administration of the same com­ pound. This has been accomplished by the biological properties exhibited by manipulating the dosage, route of inj ec­ chemically undefined bacterial somatic antigens. Simple polysaccharides like tion, and regimen 
TI - The effect of neutral and acidic polysaccharides on natural resistance of mice to bacterial challenge*
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/115.4.413
DA - 1965-10-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-effect-of-neutral-and-acidic-polysaccharides-on-natural-resistance-uBdR0vqjfi
SP - 413
EP - 420
VL - 115
IS - 4
DP - DeepDyve
ER -