TY - JOUR
AU - Altfeld, Marcus
AB - Seminars in Immunopathology (2019) 41:133–135 https://doi.org/10.1007/s00281-018-00728-x INTRODUCTION 1 2 Hanna Lotter & Marcus Altfeld Received: 15 November 2018 / Accepted: 19 November 2018 / Published online: 7 February 2019 Springer-Verlag GmbH Germany, part of Springer Nature 2018 The immune system defends us from environmental threats, for human health. Increasing evidence suggests that the func- such as infections, and detects and removes abnormal cells that tioning of our immune system is already shaped by the intra- can potentially lead to malignancies. Optimal immunological uterine environment early during immune ontogeny, and that homeostasis is achieved when the threat is removed with high altered prenatal development can have a significant impact on efficiency and at low cost (collateral tissue damage) for the the risk for infectious and autoimmune diseases later in life. host. The nature and strength of immune responses differ be- Zazara et al. [1] review the developmental origins of higher tween women and men, resulting in sex-specific differences in susceptibility to infections and immune diseases during child- the prevalence, manifestations, and outcomes of malignancies hood and throughout life, and discuss how these prenatal and autoimmune and infectious diseases. While women are in events can contribute to sex-specific differences in the 
TI - Sex differences in immunity
JF - Seminars in Immunopathology
DO - 10.1007/s00281-018-00728-x
DA - 2019-02-11
UR - https://www.deepdyve.com/lp/springer-journals/sex-differences-in-immunity-u3l4dw2i08
SP - 133
EP - 135
VL - 41
IS - 2
DP - DeepDyve
ER -