TY - JOUR
AU1 - Wang, Qian
AU2 - Zhang, Yusheng
AU3 - Xue, Haoyue
AU4 - Zeng, Yushun
AU5 - Lu, Gengxi
AU6 - Fan, Hongsong
AU7 - Jiang, Laiming
AU8 - Wu, Jiagang
AB - Ultrasound-driven bioelectronics could offer a wireless scheme with sustainable power supply; however, current ultrasound implantable systems present critical challenges in biocompatibility and harvesting performance related to lead/lead-free piezoelectric materials and devices. Here, we report a lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation, which integrates two developed lead-free sandwich porous 1-3-type piezoelectric composite elements with enhanced harvesting performance in a flexible printed circuit board. The implant is ultrasonically powered through a portable external dual-frequency transducer and generates programmable biphasic stimulus pulses in clinically relevant frequencies. Furthermore, we demonstrate ultrasound-driven implants for long-term biosafety therapy in deep brain stimulation through an epileptic rodent model. With biocompatibility and improved electrical performance, the lead-free materials and devices presented here could provide a promising platform for developing implantable ultrasonic electronics in the future.
TI - Lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation
JF - Nature Communications
DO - 10.1038/s41467-024-48250-z
DA - 2024-05-13
UR - https://www.deepdyve.com/lp/springer-journals/lead-free-dual-frequency-ultrasound-implants-for-wireless-biphasic-u1F0PYahpg
VL - 15
IS - 1
DP - DeepDyve
ER -