TY - JOUR
AU - Merigan, Thomas C.
AB - THE JOURNAL OF INFECTIOUS DISEASES • VOL. 123, NO.2· FEBRUARY 1971 © 1971 by the University of Chicago. All rights reserved. Bis-DEAE-Fluorenone: Mechanism of Antiviral Protection and Stimulation of Interferon Production in the Mouse Erik De Clercq * and Thomas C. Merigan From the Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, California The production of interferon that is stimulated by perimental viral infection. The disease studied was a variety of microorganisms, microbial extracts, induced by intranasal challenge with vesicular sto­ and synthetic polymers has been reviewed [1]. matitis virus (VSV) [6], which closely resembles Most of these have a macromolecular structure, certain natural viral infections in animals and man and only two substances of low molecular weight (e.g., poliomyelitis, rabies, and herpes simplex en­ (cycloheximide, mol wt == 281, and kanamycin, cephalitis) [7] in that the virus spreads from a mol wt == 484) have ever been reported to stimu­ site in the respiratory tract (olfactory mucosa) late production of interferon [2, 3]. The effect of through the olfactory nerves to the brain. the antibiotics was noted only at relatively high dosage levels and, with cycloheximide, interferon Materials and Methods production was correlated 
TI - Bis-DEAE-Fluorenone: Mechanism of Antiviral Protection and Stimulation of Interferon Production in the Mouse
JO - The Journal of Infectious Diseases
DO - 10.1093/infdis/123.2.190
DA - 1971-02-01
UR - https://www.deepdyve.com/lp/oxford-university-press/bis-deae-fluorenone-mechanism-of-antiviral-protection-and-stimulation-ttwXbzUaHE
SP - 190
EP - 199
VL - 123
IS - 2
DP - DeepDyve
ER -