TY - JOUR
AU - Wenzel, Richard, P.
AB - Abstract We describe an outbreak of vancomycin-resistant Enterococcus faecium (vanA phenotype) bacteremia on the oncology ward of a tertiary care community hospital. In 10 of the 11 cases the patients had leukemia and were neutropenic (median duration of neutropenia, 21 days) at the time of bacteremia. On average, patients received six antibiotic agents for a total of 61 agent-days prior to development of vancomycin-resistant E. faecium bacteremia. The mortality rate was 73%. Molecular typing of 22 isolates revealed that the majority (83%) represented a common strain, indicating nosocomial spread. When the 11 cases were compared to 22 matched control patients, gastrointestinal colonization with vancomycin-resistant E. faecium (odds ratio [denominator, 0] ∞, P = .005) and the use of antimicrobial agents with significant activity against anaerobes (metronidazole, clindamycin, and imipenem; odds ratio ∞, P= .02) were found to be risk factors for the development of vancomycin-resistant E. faecium bacteremia. Since no proven therapy for such infection exists, there is an urgent need to identify effective measures to prevent and control the development of vancomycin-resistant E. faecium bacteremia. This content is only available as a PDF. Author notes Grant support: M. B. E. was supported in part by training grant in hospital epidemiology from the National Institutes of Health (T32A1O7374). © 1995 by The University of Chicago
TI - Vancomycin-Resistant Enterococcus faecium Bacteremia: Risk Factors for Infection
JF - Clinical Infectious Diseases
DO - 10.1093/clinids/20.5.1126
DA - 1995-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/vancomycin-resistant-enterococcus-faecium-bacteremia-risk-factors-for-toAFqCcPvm
SP - 1126
EP - 1133
VL - 20
IS - 5
DP - DeepDyve
ER -