TY - JOUR AU - Dehner, Louis, P. AB - Abstract A patient with chronic lymphocytic leukemia who was treated with immunosuppressive therapy for a prolonged period presented with profound muscle weakness secondary to disseminated cryptococcosis. The infection developed despite 3 months of continuous ketoconazole therapy and was not responsive to amphotericin B or flucytosine. At autopsy, Cryptococcus neoformans was present in all sampled skeletal muscles, myocardium, and muscularis propria of the gastrointestinal tract but was not identified in either the central nervous system or the lungs. A review of the English-language literature failed to identify a similar case with such profound myotropism due to Cryptococcus. This case demonstrates that cryptococcosis should be considered in the differential diagnosis of an immunocompromised host presenting with muscle weakness. This content is only available as a PDF. © 1989 by The University of Chicago TI - Profound Muscle Weakness as the Presenting Feature of Disseminated Cryptococcal Infection JF - Clinical Infectious Diseases DO - 10.1093/clinids/11.6.970 DA - 1989-11-01 UR - https://www.deepdyve.com/lp/oxford-university-press/profound-muscle-weakness-as-the-presenting-feature-of-disseminated-tTZhAvwJd0 SP - 970 EP - 974 VL - 11 IS - 6 DP - DeepDyve ER -