TY - JOUR
AU - 
AB - <jats:title>Abstract</jats:title>
               <jats:p>It is well known that cannabinoid receptors have critical roles in immune homeostasis. This includes the CB1 receptor, which is encoded on by the Cnr1 gene. Previous work by others using the EAE model in ABH Cnr1−/− mice showed that while disease severity and onset were similar between wild type (WT) and Cnr1−/− mice, recovery from a relapse was better in WT mice suggesting a level of neuroprotection mediated by the CB1 receptor. In this study, we used the active EAE model in Cnr1−/− and WT C57BL/6 littermates to determine the importance of the CB1 receptor in disease progression by examining both the peripheral and neural immune response. We found clinical disease to be more severe in Cnr1−/− mice as compared to WT mice, which corresponded with significant increases of IFNγ from supernatants of restimulated splenocytes as determined by ELISA. Our results also showed that IL17A was modestly higher in the serum and culture supernatants of the Cnr1−/− mice as compared to WT mice, and histologic analysis of spinal sections showed modestly higher levels of neuroinflammation in Cnr1−/− mice as compared to WT mice. This suggests that CB1 receptors may have an immunoregulatory effect in the peripheral immune response of EAE, which combined with the neuroprotective effect via CB1 found in the other study, ultimately leads to less severe clinical disease in WT mice.</jats:p>
TI - The role of CB1 in experimental autoimmune encephalomyelitis (EAE)
JO - The Journal of Immunology
DO - 10.4049/jimmunol.202.supp.180.12
DA - 2019-05-01
UR - https://www.deepdyve.com/lp/crossref/the-role-of-cb1-in-experimental-autoimmune-encephalomyelitis-eae-tP9Ns9XUfd
SP - 180.12
EP - 180.12
VL - 202
IS - 1_Supplement
DP - DeepDyve
ER -