TY - JOUR
AU1 - Jones, William G.
AU2 - Barber, Annabel E.
AU3 - Kapur, Sandip
AU4 - Hawes, Arthur J.
AU5 - Fahey, Thomas J.
AU6 - Minei, Joseph P.
AU7 - Shires, G. Tom
AU8 - Calvano, Steve E.
AU9 - Shires, G. Tom
AB - Abstract • Burn wound sepsis in rats results in sustained corticosterone elevations and the prolonged presence of translocated bacteria in the mesenteric lymph nodes (MLNs). To determine if survival of bacteria in the MLNs may be influenced by pathophysiologic corticosterone levels, MLNs were quantitatively analyzed from rats randomized to the following groups: burn wound sepsis (BI); BI with adrenocortical response attenuated by cyclosporine (cyclosporine/BI); or cyclosporine/BI with corticosterone replacement (cyclosporine/BI + P). Although rates of bacterial translocation were similar, corticosterone levels were significantly different among the three groups and correlated with the number of lymphocytes and the number of enteric bacteria present per gram of MLN. Thus, pathophysiologic elevations of corticosterone levels during sepsis may exert an effect that allows survival of translocated bacteria in the MLNs of rats, perhaps due to glucocorticoid-associated alterations in regional immunity. (Arch Surg. 1991;126:50-55) References 1. Berg RD, Owens WE. Inhibition of translocation of viable E coli from the gastrointestinal tract of mice by bacterial antagonism . Infect Immun . 1979;25:820-827. 2. Maejima K, Deitch EA, Berg RD. Bacterial translocation from the gastrointestinal tracts from rats receiving thermal injury . Infect Immun . 1984; 43:6-10. 3. Jones WG, Minei JP, Barber AE, et al. Bacterial translocation and intestinal atrophy after thermal injury and burn wound sepsis . Ann Surg . 1990;211:399-405.Crossref 4. Deitch EA, Maejima K, Berg RD. Effect of oral antibiotics and bacterial overgrowth in the translocation of the gastrointestinal tract microflora in burned rats . J Trauma . 1985;25:385-392.Crossref 5. Deitch EA, Berg R. 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TI - Pathophysiologic Glucocorticoid Levels and Survival of Translocating Bacteria
JF - Archives of Surgery
DO - 10.1001/archsurg.1991.01410250056009
DA - 1991-01-01
UR - https://www.deepdyve.com/lp/american-medical-association/pathophysiologic-glucocorticoid-levels-and-survival-of-translocating-tHgxS07O9h
SP - 50
EP - 55
VL - 126
IS - 1
DP - DeepDyve
ER -