TY - JOUR
AU1 - Yang, Xiaoqiang
AU2 - Zhu, Bo
AU3 - Dong, Tungalag
AU4 - Pan, Pengju
AU5 - Shuai, Xintao
AU6 - Inoue, Yoshio
AB - Interactions between the anticancer drug quercetin and biodegradable polyesters within micelles were investigated by DSC, WAXD, and UV analyses. For micelles based on poly(ethylene glycol) methyl ether‐block‐poly(ε‐caprolactone) (MPEG‐PCL), DSC analysis indicated that the interactions were between the hydrophobic core and the drug within the micelle. For micelles based on poly(ethylene glycol) methyl ether‐block‐poly(L‐lactide) (MPEG‐PLLA), the interactions were between the hydrophobic core and the drug and between hydrophilic segments and the drug. WAXD results indicated that no crystalline phase of the drug was found in either of the micelle types. Based on the DSC and WAXD results, two probable micelle structures were proposed. The UV spectra revealed the presence of hydrogen bonding as the main interaction between the drug and the polyesters. In vitro studies demonstrated that quercetin release from micelles was sustained and was affected by the polymer–drug interaction.
TI - Interactions between an Anticancer Drug and Polymeric Micelles Based on Biodegradable Polyesters
JF - Macromolecular Bioscience
DO - 10.1002/mabi.200800085
DA - 2008-12-08
UR - https://www.deepdyve.com/lp/wiley/interactions-between-an-anticancer-drug-and-polymeric-micelles-based-t4xMyzuE2I
SP - 1116
EP - 1125
VL - 8
IS - 12
DP - DeepDyve
ER -