TY - JOUR
AU - Hahn, Sei Kwang
AB - Abstract Theranostic systems have been widely investigated for application in the diagnostic therapy of cancers. In this work, hyaluronic acid (HA)-doxorubicin (DOX) conjugate was successfully synthesized by the amide bond formation between amine groups of DOX and carboxylic groups of HA activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysulfosuccinimide. The 1H nuclear magnetic resonance (NMR) and gel permeation chromatographic (GPC) analyses confirmed the successful synthesis of HA-DOX conjugates. HA-DOX conjugates self-assembled to micelle-like nanoparticles in aqueous solution. In vitro anti-proliferation tests of cancer cells confirmed the anti-tumor effect of HA-DOX conjugate micelles. For further application, the micelles were coated with a gold (Au) half-shell by the thermal vapor deposition method, which might contribute to prolonging the residence time in the body with a versatile surface modification on the Au surface. TEM analysis confirmed the successful Au coating on HA-DOX conjugate micelles with a thickness of 15 nm. The Au half-shell-coated HADOX conjugate micelles might be successfully exploited for cancer theranostic applications such as chemotherapy, hyperthermia, and bioimaging.
TI - Gold half-shell coated hyaluronic acid-doxorubicin conjugate micelles for theranostic applications
JF - "Macromolecular Research"
DO - 10.1007/s13233-012-0062-x
DA - 2012-03-01
UR - https://www.deepdyve.com/lp/springer-journals/gold-half-shell-coated-hyaluronic-acid-doxorubicin-conjugate-micelles-t0DmuFbgGf
SP - 277
EP - 282
VL - 20
IS - 3
DP - DeepDyve
ER -