TY - JOUR
AU - Nielsen, Poul
AB - A 3′‐C‐hydroxymethyl‐branched Locked Nucleic Acid (LNA) monomer 3 was synthesized from diacetone‐α‐D‐glucose taking advantage of a stereoselective Grignard reaction for the introduction of a vinyl group, an aldol/Cannizzarro sequence for introducing the 4′‐substituent, oxidative cleavage of the vinyl group using a RuO4‐based protocol, Vorbrüggen‐type nucleobase coupling and finally the ring closure by ether formation giving the bicyclic skeleton. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
TI - Synthesis of the 3′‐ C ‐Hydroxymethyl‐Branched Locked Nucleic Acid Thymidine Monomer
JF - European Journal of Organic Chemistry
DO - 10.1002/ejoc.200800716
DA - 2008-12-01
UR - https://www.deepdyve.com/lp/wiley/synthesis-of-the-3-c-hydroxymethyl-branched-locked-nucleic-acid-spfRL0Gchb
SP - 5715
EP - 5722
VL - 2008
IS - 34
DP - DeepDyve
ER -