TY - JOUR
AU - Zuberbier, Torsten
AB - Human skin mast cells proliferated in the presence of interleukin (IL)-4+SCF (expanding 18-fold in 8 weeks) and acquired profound responsiveness towards high affinity IgE receptor (FcεRI) cross-linking, liberating about 75% of their histamine. In a proof-of-concept, we found that these cells are useful for pharmacological testing. Even a subtle inhibition of degranulation can be visualized. This model might prove valuable in tests of novel anti-allergic drugs.
TI - Long-term cultured human skin mast cells are suitable for pharmacological studies of anti-allergic drugs due to high responsiveness to FcεRI cross-linking.
JO - Bioscience, biotechnology, and biochemistry
DO - 10.1271/bbb.100745
DA - 2011-06-06
UR - https://www.deepdyve.com/lp/pubmed/long-term-cultured-human-skin-mast-cells-are-suitable-for-soZSiLytyW
SP - 382
EP - 4
VL - 75
IS - 2
DP - DeepDyve
ER -