TY - JOUR
AU - Rendell, Marc
AB - The etiologies of a variety of skin conditions associated with diabetes have not been fully explained. One possible etiological factor is diabetic microangiopathy, which is known to affect the eyes and kidneys in patients with diabetes. There are many mechanisms by which diabetes may cause microangiopathy. These include excess sorbitol formation, increased glycation end products, oxidative damage, and protein kinase C overactivity. All of these processes occur in the skin, and the existence of a cutaneous diabetic microangiopathy has been well demonstrated. These microangiopathic changes are associated with abnormalities of skin perfusion. Because the skin plays a thermoregulatory role, there is significant capillary redundancy in normal skin. In diabetic patients, loss of capillaries is associated with a decrease in perfusion reserve. This lost reserve is demonstrable under stressed conditions, such as thermal stimulation. The associated failure of microvascular perfusion to meet the requirements of skin metabolism may result in diverse skin lesions in patients with diabetes.
TI - Manifestations of Cutaneous Diabetic Microangiopathy
JF - American Journal of Clinical Dermatology
DO - 10.2165/00128071-200506040-00003
DA - 2012-08-21
UR - https://www.deepdyve.com/lp/springer-journals/manifestations-of-cutaneous-diabetic-microangiopathy-sibqz5IsjC
SP - 225
EP - 237
VL - 6
IS - 4
DP - DeepDyve
ER -