TY - JOUR AB - late pregnancy, and both pathologists and obstetricians had formed the belief that normal pregnancy produced a functional derangement from nonpregnancy standards. Almost everyone noted the low percentage of urea nitrogen in the urines and increased percentages of undetermined nitrogen. J. Ewing and C. G. L. Wolf (Am. J . Obstet. 66, 289, see esp. p . 293 (1907))and many others were led astray because they had not kept nitrogen balances on their pregnancy cases. I they had done so, it would have been f apparent that the lowest percentage of urea nitrogen occurs simultaneously with greatest nitrogen retention by the product of conception. It took a novice to furnish the explanation of the so-called “functional derangement.” JOHN MURLIN, R. PH.D. Department of Physiolog?j and Vital Economics University of Rochester School of Medicine Rochester, New Yorlc GLUCAGON It is now generally recognized that pancreatic extracts contain a protein, factor which is capable of raising blood glucose, presumably by stimulating hepatic glycogenolysis. This factor which C. P. Kimball and J. R. Murlin called “glucagon” ( J . Biol. Chem. 68, 337 (1923)) recently has been separated from insulin by selective precipitation, and isolated in crystalline form (A. Staub, L. Sinn, TI - GLUCAGON JO - Nutrition Reviews DO - 10.1111/j.1753-4887.1954.tb03234.x DA - 1954-05-01 UR - https://www.deepdyve.com/lp/oxford-university-press/glucagon-sPLI9zn0ys SP - 132 VL - 12 IS - 5 DP - DeepDyve ER -