TY - JOUR
AU - Tyler, Kenneth L.
AB - BASIC SCIENCE SEMINARS IN NEUROLOGY SECTION EDITOR: HASSAN M. FATHALLAH-SHAYKH, MD Polymerase Chain Reaction in the Diagnosis and Management of Central Nervous System Infections Roberta L. DeBiasi, MD; Kenneth L. Tyler, MD olymerase chain reaction (PCR) is a broadly applied laboratory test for the diagnosis of a wide variety of central nervous system (CNS) diseases, including genetic and auto- 1,2 immune diseases, malignant neoplasms, and infections. With its ability to detect minute P amounts of DNA or RNA contained in tissues or fluids, PCR has improved the rapidity and accuracy of diagnosis, enhanced understanding of pathogenesis, and helped identify infec- tious causes for diseases previously considered idiopathic. In addition, PCR can be performed on a variety of tissues preserved in different ways—even archival specimens can be used to provide important epidemiological information. By making quick and precise diagnoses, appropriate treat- ments can be instituted, and unnecessary or invasive investigations can be avoided. METHODS age (DNA polymerase). By supplying nucleotides in vast molar excess and by The power of PCR results from its ability making use of a thermostable DNA poly- to synthesize millions of copies of a spe- merase (usually Taq polymerase), a new cific gene segment in vitro, 
TI - Polymerase Chain Reaction in the Diagnosis and Management of Central Nervous System Infections
JF - JAMA Neurology
DO - 10.1001/archneur.56.10.1215
DA - 1999-10-01
UR - https://www.deepdyve.com/lp/american-medical-association/polymerase-chain-reaction-in-the-diagnosis-and-management-of-central-s2IOXJnwcc
SP - 1215
EP - 1219
VL - 56
IS - 10
DP - DeepDyve
ER -