TY - JOUR
AU - Arcadi, Antonio
AB - A viable one‐pot synthesis of challenging 4H‐[3,4‐c]quinolone‐4,5(6H)‐diones by the reaction of β‐(2‐aminophenyl)‐α,β‐ynones with ethyl malonyl chloride is described. Their further elaboration in the presence of an excess of 40 % methyl amine aqueous solution in EtOH gives the benzo[c][2,7]naphthyridine‐4,5(3H,6H)‐diones of pharmacological interest in high yields. The product selectivity control of the divergent sequential condensation/C‐annulation/intramolecular transesterification vs condensation/O‐annulation/ring opening reactions of β‐(2‐aminophenyl)‐α,β‐ynones with malonyl chloride under metal free conditions has been addressed.
TI - Divergent Sequential Reactions of β‐(2‐Aminophenyl)‐α,β‐ynones with Malonyl Chloride
JO - European Journal of Organic Chemistry
DO - 10.1002/ejoc.202201187
DA - 2022-12-06
UR - https://www.deepdyve.com/lp/wiley/divergent-sequential-reactions-of-2-aminophenyl-ynones-with-malonyl-rwEGmhPyjo
VL - 2022
IS - 45
DP - DeepDyve
ER -