TY - JOUR
AU - Winkelman, John W.
AB - COMMENTARY http://dx.doi.org/10.5665/sleep.1854 Commentary on Morgan et al. Cortical GABA levels in primary insomnia. SLEEP 2012;35:807-814. 1 2,3 2,4 David T. Plante, MD ; J. Eric Jensen, PhD ; John W. Winkelman, MD, PhD 1 2 Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI; Department of Psychiatry, Harvard Medical 3 4 School, Boston, MA; Brain Imaging Center, McLean Hospital, Belmont, MA; Division of Sleep Medicine, Brigham and Women’s Hospital, Boston, MA 10 1 There are several lines of evidence that suggest γ-aminobutyric nary study is not comparable to the work by Morgan et al., acid (GABA), the primary inhibitory neurotransmitter in the the more recent replication study similarly evaluated a voxel central nervous system (CNS), plays a role in the etiology of in the occipital cortex. However, closer scrutiny of the voxel chronic insomnia. In this issue of SLEEP, Morgan et al. re- placement suggests that these voxels (of different dimensions) port a 12% increase in occipital GABA, measured using pro- had limited overlap, with the voxel by Morgan and colleagues ton magnetic resonance spectroscopy (1H-MRS), in primary being positioned more posteriorly. Also, reductions of GABA insomnia (PI) subjects relative to healthy controls. Moreover, 
TI - The Role of GABA in Primary Insomnia
JF - SLEEP
DO - 10.5665/sleep.1854
DA - 2012-06-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-role-of-gaba-in-primary-insomnia-rpy0ldoox0
SP - 741
EP - 742
VL - 35
IS - 6
DP - DeepDyve
ER -