TY - JOUR
AU - Simpson, R.
AB - Integrins are a family of heterodimeric transmembrane glycoproteins that are known to mediate cell‐cell and cell‐matrix interactions. Members of the VLA (very late activation) family, which consists of β1 integrin in association with the VLA α chains (α1–6), mediate adhesion of a wide range of cells to matrix proteins, such as fibronectin, collagen, and laminin, and may therefore be important for cell‐matrix interactions in bone. Integrin expression in human bone was studied immunohistochemically using cryostat sections of fracture callus, tumor‐associated reactive bone, and neonatal costochondral junctions, with a panel of well‐characterized antibodies against β1–4 integrins, α1–6 and αv integrins, and the αvβ3 dimer (the classic vitronectin receptor). All cell types present in bone expressed β1 and α5 integrins; a subpopulation of osteoblastic cells expressed α4. The αv was uniformly expressed by osteoblasts but was heterogeneously expressed by osteocytes. Osteoclasts also expressed α2, αv, and αvβ3. These results demonstrate differential expression of a restricted range of integrins in bone. This supports the possibility that integrins may mediate the differing interactions of cells of the osteoblast and osteoclast lineages with the matrix of bone.
TI - Integrin expression in human bone
JO - Journal of Bone and Mineral Research
DO - 10.1002/jbmr.5650080503
DA - 1993-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/integrin-expression-in-human-bone-rdU0a0bGZP
SP - 527
EP - 533
VL - 8
IS - 5
DP - DeepDyve
ER -