TY - JOUR
AU - Cone, Sandra B.
AB - Abstract • Pattern electroretinograms (P-ERGs) and visual evoked potentials (VEPs) were recorded in 35 patients with multiple sclerosis and in 35 age-matched normal subjects. Four patterns of abnormalities were noted in the group with multiple sclerosis. The most frequent abnormality consisted of the following: normal P-ERG, delayed P100, and prolonged interpeak interval between the b-wave of the P-ERG and P100 (retinocortical time). This pattern indicates demyelination of the optic nerve. A second pattern consisted of absent P-ERG and absent VEP. This pattern was associated with optic atrophy and/or central scotoma, indicating severe optic nerve axonopathy with retrograde degeneration of ganglion cells. A third pattern consisted of normal P-ERG and absent VEP, suggesting a total block of transmission at the optic nerve. A fourth pattern consisted of present but low-amplitude P-ERG, delayed VEP, and prolonged retinocortical time, indicating a demyelinating process with partial axonal involvement. The concomitant use of P-ERG and VEP results in a better classification of the type and severity of dysfunction affecting the optic nerve. The prognostic value of the four patterns for recovery of visual function is discussed. References 1. Asselman P, Chadwick DW, Marsden CD: Visual evoked responses in the diagnosis and management of patients suspected of multiple sclerosis . Brain 1975;8:261-282.Crossref 2. Becker WJ, Richards IM: Serial pattern shift visual evoked potentials in multiple sclerosis . Can J Neurol Sci 1984;11:53-59. 3. Bodis-Wollner I, Hendley CD, Mylin LH, et al: Visual evoked potentials and the visuogram in multiple sclerosis . Ann Neurol 1979;5:40-47.Crossref 4. Bottcher J, Trojaborg W: Follow-up of patients with suspected multiple sclerosis: A clinical and electrophysiological study . 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TI - Simultaneous Recording of Pattern Electroretinography and Visual Evoked Potentials in Multiple Sclerosis: A Method to Separate Demyelination From Axonal Damage to the Optic Nerve
JF - Archives of Neurology
DO - 10.1001/archneur.1986.00520120031012
DA - 1986-12-01
UR - https://www.deepdyve.com/lp/american-medical-association/simultaneous-recording-of-pattern-electroretinography-and-visual-raliHD6314
SP - 1247
EP - 1252
VL - 43
IS - 12
DP - DeepDyve
ER -