TY - JOUR
AU1 - MILLA, P J
AB - 148 Gut 1999;44:148–152 Commentaries See article on page 246 children with Hirschsprung’s disease has shown that about Endothelins, pseudo-obstruction and 10% carry mutations of either ETR-B, ET-3 or ECE-1. Hirschsprung’s disease The eVects of these genetic defects is to curtail neural crest migration in the distal colon and this is associated with localised overexpression of extracellular matrix molecules. Using transgenic lines of mice which are either ETR-B It has been known since the 1950s that the enteric nervous deficient or ET-3 deficient, Kapur and colleagues have system is formed from cells that arise from the neural shown that in ETR-B deficient mice enteric nervous crest. The enteric neurones mainly arise from the vagal system precursors can colonise the murine hind gut when neural crest of the developing hind brain and colonise the they are surrounded by wild type enteric nervous system gut in a rostro caudal migration but some seem to arrive in precursors. Further wild type enteric nervous system the hind gut from the lumbosacral level via a caudo rostral precursors will fail to colonise the hind gut when wave of colonisation. The neural crest cells that migrate surrounded by ETR-B deficient ones. This strongly and colonise the 
TI - Endothelins, pseudo-obstruction and Hirschsprung’s disease
JF - Gut
DO - 10.1136/gut.44.2.148
DA - 1999-02-01
UR - https://www.deepdyve.com/lp/british-medical-journal/endothelins-pseudo-obstruction-and-hirschsprung-s-disease-rSGLvoOCfD
SP - 148
EP - 149
VL - 44
IS - 2
DP - DeepDyve
ER -