TY - JOUR
AU - Gerson, Stanton L.
AB - Abstract • To assess the value of high-dose dexamethasone therapy in preventing the gastrointestinal (GI) side effects of chemotherapy, a randomized double-blind study was conducted in women receiving outpatient therapy for breast cancer. Single-dose dexamethasone sodium phosphate (10 mg) or placebo was administered intravenously in 57 trials in 22 women immediately before chemotherapy. Questionnaires (administered before therapy and 24 hours later) were compared for evidence of nausea, vomiting, and anorexia produced by chemotherapy. No GI Intolerance to chemotherapy was noted in 24 (83%) of the 29 dexamethasone trials v 16 (57%) of the 28 placebo trials. Dexamethasone trials produced the following results: no side effects in 50% (14/29), insomnia the night after chemotherapy in 21% (6/29), an increase in energy levels in 24% (7/29), and an improvement in mood in 14% (4/29). High-dose dexamethasone therapy has useful application in alleviating the emetic effects of cancer chemotherapy. (Arch Intern Med 1983;143:1347-1349) References 1. Seigel LJ, Longo DL: The control of chemotherapy-induced emesis: Review. Ann Intern Med 1981;95:352-359.Crossref 2. Laszlo J, Lucas VS Jr: Emesis as a critical problem in chemotherapy, editorial. N Engl J Med 1981;305:948-949.Crossref 3. Frytak S, Moertel CG: Management of nausea and vomiting in the cancer patient. JAMA 1981;245:393-396.Crossref 4. Gralla RJ, Itri LM, Pisko SE, et al: Antiemetic efficacy of high-dose metoclopramide: Randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting. N Engl J Med 1981;305:905-909.Crossref 5. Sallan SE, Cronin C, Zelen M, et al: Antiemetics in patients receiving chemotherapy for cancer: A randomized comparison of delta-9-tetrahydrocannabinol and prochlorperazine. N Engl J Med 1980;302:135-138.Crossref 6. Rich WM, Abdulhayoglu G, Di Saia PH: Methylprednisolone as an antiemetic during cancer chemotherapy: A pilot study. Gynecol Oncol 1980;9:193-198.Crossref 7. Aapro MS, Alberts DS: Dexamethasone as an antiemetic in patients treated with cisplatinum, letter. N Engl J Med 1981;305:520. 8. Lee BJ: Methylprednisolone as an antiemetic, letter. N Engl J Med 1981;304:486. 9. Aapro MS, Alberts DS: High-dose dexamethasone for prevention of cisplatin-induced vomiting. Cancer Chemother Pharmacol 1981;7:11-14. 10. Canellos GP, Pocock SJ, Taylor SG III, et al: Combination chemotherapy for metastatic breast carcinoma: Prospective comparison of multiple drug therapy with L-phenylalanine mustard. Cancer 1976;38:1882-1886.Crossref
TI - Antiemetic Efficacy of Dexamethasone Therapy in Patients Receiving Cancer Chemotherapy
JF - Archives of Internal Medicine
DO - 10.1001/archinte.1983.00350070063012
DA - 1983-07-01
UR - https://www.deepdyve.com/lp/american-medical-association/antiemetic-efficacy-of-dexamethasone-therapy-in-patients-receiving-rDXdRZ9ebJ
SP - 1347
EP - 1349
VL - 143
IS - 7
DP - DeepDyve
ER -