TY - JOUR
AU1 - Secora, Alex
AU2 - Alexander, G.
AU3 - Ballew, Shoshana
AU4 - Coresh, Josef
AU5 - Grams, Morgan
AB - Background Chronic kidney disease (CKD) afflicts many older adults and increases the risk for medication-related adverse events. Objective The aim of this study was to assess the prevalence and associated morbidity and mortality of polypharmacy (use of several medications concurrently), and potentially inappropriate medication (PIM) use in older adults, looking for dif- ferences by CKD status. Methods We quantified medication and PIM use (from Beers criteria, the Screening Tool of Older People’s Prescriptions, and Micromedex ) by level of estimated glomerular filtration rate (eGFR) for participants aged 65 years or older attending a baseline study visit in the Atherosclerosis Risk in Communities study (n =6392). We used zero-inflated negative binomial and Cox proportional hazards regressions to assess the relationship between baseline polypharmacy, PIM use, and subsequent hospitalization and death. Results Mean age at baseline was 76 (± 5) years, 59% were female, and 29% had CKD (eGFR < 60 ml/min/1.73 m ). Overall, participants reported 6.1 (± 3.5) medications and 2.3 (± 2.2) vitamins/supplements; 16% reported ≥ 10 medications; 31% reported a PIM based on their age. On average, participants with CKD reported more medications. A PIM based on kidney function was used by 36% of those with eGFR < 30 ml/min/1.73 m . 
TI - Kidney Function, Polypharmacy, and Potentially Inappropriate Medication Use in a Community-Based Cohort of Older Adults
JF - Drugs & Aging
DO - 10.1007/s40266-018-0563-1
DA - 2018-07-24
UR - https://www.deepdyve.com/lp/springer-journals/kidney-function-polypharmacy-and-potentially-inappropriate-medication-r8rqYaPYeL
SP - 735
EP - 750
VL - 35
IS - 8
DP - DeepDyve
ER -