TY - JOUR
AB - Editor Vivian Fonseca, MD Division of Endocrinology, Tulane University Medical Center, 1430 Tulane Avenue (SL 53), New Orleans, LA 70112, USA. E-mail: vfonseca@tulane.edu Takamura T, Sakurai M, Ota T, et al.: Genes for systemic vascular complications are differentially expressed in the livers of type 2 diabetic patients. Diabetologia 2004, 47:638–647. Significance: It is now possible to study the expression of various genes in tissue obtained from patients using microarray techniques. Such a study improves our understanding of the pathophysiology of complications and in the future may lead to improved therapies targeting these processes. This study is among the first to examine expression of a large number of genes thought to be important in the development of the complications of diabetes. These findings suggest that gene expression profiles in the liver of patients with type 2 diabetes are different from that in those without the disease, and are compatible with much that we know about the pathophysiology of diabetic vascular complications. Findings: Tissue obtained from liver biopsies from 12 patients with type 2 diabetes were compared with biopsies from nine patients without diabetes. Complementary DNA (cDNA) microarrays, con- sisting of 1080 human cDNAs, were made in order assay gene expression 
TI - Literature alert
JF - Current Diabetes Reports
DO - 10.1007/s11892-004-0031-7
DA - 2004-05-15
UR - https://www.deepdyve.com/lp/springer-journals/literature-alert-r5wkUueFs5
SP - 321
EP - 323
VL - 4
IS - 5
DP - DeepDyve
ER -