TY - JOUR AU - RIMINGTON, C. AB - THE BRITISH JOURNAL OF DERMATOLOGY OCTOBER 195:3 G. C. WELLS, M.B., M.R.C.P., AND C. RIMINGTON , M.A., Ph.D., D.Sc. Department of Dermatology and Nuffield Unit for the Investigation of Pyrrole Pigment Metabolism, Dejiartn^ent of Chemical Pathologj^ University College Hospital Medical School, London. PHOTOSENSITIVITY is not uncommon among dermatological patients, but in relatively few cases is the photosensitizing substance identified and the factors responsible for its appearance established. That porphyrins are photodynami- cally active and may lead to severe clinical photosensitization has been recog- nized for some time. Giinther (1922) in his early work on the porphyi'ias des- cribed as poiyhyria congenita a relatively rare familial disease in which photo- sensitivity was present from birth, and was accompanied by the deposition of porphyrin in the bones and teeth and by the excretion of large quantities of porphyi'in in the urine. Later studies by Borst and Konigsdorffer (1929) on the pathological side, and by H. Fischer and his collaborators (1925) on the chemical side, added much to our knowledge of the condition. The urinary porp]i3Tins were recognised as uroporphyrin (containing 8 carboxyl groups) and coproporphyrin (containing 4 carboxyl groups), and the effect of these upon animals and micro-organisms was studied in TI - STUDIES ON A CASE OF PORPHYRIA CUTANEA TARDA. JF - British Journal of Dermatology DO - 10.1111/j.1365-2133.1953.tb13165.x DA - 1953-10-01 UR - https://www.deepdyve.com/lp/oxford-university-press/studies-on-a-case-of-porphyria-cutanea-tarda-qlYHogf0Y5 SP - 337 EP - 351 VL - 65 IS - 10 DP - DeepDyve ER -