TY - JOUR
AU1 - Zhang, Qi
AU2 - Wang, Minji
AU3 - Hu, Xuqiao
AU4 - Yan, Aixin
AU5 - Ho, Pak-Leung
AU6 - Li, Hongyan
AU7 - Sun, Hongzhe
AB - The emergence and rapid spread of the mobile colistin resistance gene mcr-1 among bacterial species and hosts significantly challenge the efficacy of “last-line” antibiotic colistin. Previously, we reported silver nitrate and auranofin serve as colistin adjuvants for combating mcr-1-positive bacteria. Herein, we uncovered more gold-based drugs and nanoparticles, and found that they exhibited varying degree of synergisms with colistin on killing mcr-1-positive bacteria. However, pre-activation of the drugs by either glutathione or N-acetyl cysteine, thus releasing and accumulating gold ions, is perquisite for their abilities to substitute zinc cofactor from MCR-1 enzyme. X-ray crystallography and biophysical studies further supported the proposed mechanism. This study not only provides basis for combining gold-based drugs and colistin for combating mcr-1-positive bacterial infections, but also undoubtedly opens a new horizon for metabolism details of gold-based drugs in overcoming antimicrobial resistance.Graphical abstract[graphic not available: see fulltext]
TI - Gold drugs as colistin adjuvants in the fight against MCR-1 producing bacteria
JF - JBIC Journal of Biological Inorganic Chemistry
DO - 10.1007/s00775-022-01983-y
DA - 2023-03-01
UR - https://www.deepdyve.com/lp/springer-journals/gold-drugs-as-colistin-adjuvants-in-the-fight-against-mcr-1-producing-qbTULxRfmz
SP - 225
EP - 234
VL - 28
IS - 2
DP - DeepDyve
ER -