TY - JOUR
AU - Peshkin, Beth
AB - Purpose of Review The availability of multigene cancer panel testing (MCPT) has revolutionized the care of individuals and families at risk for hereditary cancer. This review discusses fundamental components of genetic counseling, test selection, result interpretation, and follow-up related to MCPT. Recent Findings Routine use of MCPT increases the diagnostic yield for major hereditary cancers such as breast, ovarian, and colon, with the identification of pathogenic variants in high- and moderate-penetrance genes. In addition, the larger the panel, the more likely one or more variants of uncertain significance will be identified. Furthermore, although index cases who test negative after multigene panel testing may derive some reassurance about hereditary risk, assessment and management based on personal and family history are the keys. Summary Given the complexity of MCPT, pre- and post-test genetic counseling approaches have been adapted to optimize the delivery of information and support to patients and their families. . . . Keywords Cancer genetics Genetic counseling Multigene cancer panels Cancer genetic testing Introduction leveraged next-generation sequencing technologies to simul- taneously test for pathogenic variants (PVs) in several cancer Genetic counseling and testing for hereditary cancer risk is a susceptibility genes, also known as multigene cancer panel standard part 
TI - Multigene Cancer Panels: Implications for Pre- and Post-test Genetic Counseling
JO - Current Genetic Medicine Reports
DO - 10.1007/s40142-019-00173-8
DA - 2019-11-04
UR - https://www.deepdyve.com/lp/springer-journals/multigene-cancer-panels-implications-for-pre-and-post-test-genetic-qRttVpMwul
SP - 169
EP - 179
VL - 7
IS - 4
DP - DeepDyve
ER -